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Their dual mechanismsmicrobiota regulation and barrier enhancementinclude stimulation of beneficial bacteria such as Lactobacillus and Bifidobacterium , elevation of SCFA production (e.g., butyrate as an epithelial energy source, acetate for Treg differentiation), inhibition of TLR4/NF-B inflammatory signaling, and activation of the Nrf2/HO-1 antioxidant pathway

Berberine Suppresses the TPA-Induced MMP-1 and MMP-9 Expressions through the Inhibition of PKC- in Breast Cancer Cells

2012;197(4):2245 Joybari AY, Sarbaz S, Azadeh P, Mirafsharieh SA, Rahbari A, Farasatinasab M, Mokhtari M

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The concentration of deoxyguanosine (OdG) is increased in CNS tissue and biofluid samples in ALS patients having DNA damage