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However, the review emphasized that the majority of studies utilized small rodent models, and efficacy in humans remains to be confirmed through adequately powered clinical trials

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Figure 3 illustrates a method-specific two-step NEM workflow rather than a universal LC-MS/MS protocol

Raper SE, Yudkoff M, Chirmule N et al (2002) A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency

In this Review, we describe the evidence for abnormalities in energy metabolism and mitochondrial function in migraine, with a focus on clinical data (including neuroimaging, biochemical, genetic and therapeutic studies), and consider the relationship of these abnormalities with the abnormal sensory processing and cerebral hyper-responsivity observed in migraine