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Barisic M, Balenovic D, Klicek R, et al

The cost and availability of these drugs are also important considerations, as well as the potential consequences of taking them off for a period of time, such as a shortage, and the possibility that better drugs may be developed in the future 2m40s

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Risk of liver injury among methotrexate users: a meta-analysis of randomised controlled trials

Alternative Therapies in Health and Medicine , 31(5), 2024

Some practitioners implement cycling to theoretically prevent receptor desensitization, provide physiological breaks, or manage costs, though evidence supporting these approaches is limited