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101 Whereas, the classical explanation is that, while hydroxychloroquine impaired phago/lysosomal function, it also appears to work in a lysosome-independent manner by impacting on intracellular TLRs, particularly TLR9, by inhibiting the production of TNF, and by interfering with the processing of the conversion of the membrane-bound pro-TNF into soluble mature protein
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Diagnostic criteria varied across studiessome applied Rome IV/III criteria, others used ICD-based diagnoses, validated rating scales (PHQ-9, HAMD), or self-report
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Miguez-Pacheco, V., Hench, L
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