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When you eat, your blood sugar rises, giving you a boost of energy

On the other hand, an initial early stepwise increase from monotherapy to combination therapy when A1C is above target may maintain durability similar to that which can be achieved by starting with combination therapy or triple therapy as suggested by DeFronzo (11)

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Mechanistically, since SGLT2 is not expressed in cardiomyocytes, SGLT2 inhibitors exert their cardioprotective effects indirectly by targeting noncardiomyocytes, such as by inducing diuresis, modulating neurohormonal activation, and improving metabolism, rather than through direct actions on cardiomyocytes