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The inability of the multi-agonists to restore gonadal function in PWA mice is likely due to chronic exposure to fixed concentrations of the exogenous androgen, DHT, which may limit the eventual beneficial effects of the compounds at the gonadal level, even when substantial metabolic improvements are achieved

Some of any weight lost on these medicines comes from lean tissue rather than fat

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J Manipulative Physiol Ther 1995

[24] Sibutramine, a serotonin and epinephrine uptake inhibitor, was approved the same year for appetite suppression

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