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435 Patients carrying a biallelic SEL1L variant (p.Cys141Tyr) exhibit both ERAD-associated neurodevelopmental disorders with onset in infancy (ENDI) syndrome and infantile-onset agammaglobulinemia with no mature B cells, leading to recurrent infections and early mortality

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Serious side effects like pancreatitis or severe allergic reactions are rare but require immediate medical attention and discontinuation

314 Circulating FFAs are the primary causes of liver fat accumulation in MAFLD that mainly occur due to lipolysis of adipose tissues, and partially from excess lipoprotein