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Consult your provider if you experience severe or persistent nausea and vomiting that prevents adequate food or fluid intake, signs of pancreatitis including severe abdominal pain , vision changes or signs of diabetic retinopathy progression if you have diabetes, severe constipation lasting more than a week despite interventions, rapid heart rate or chest pain, or complete lack of appetite suppression or weight loss after reaching 1mg dose for at least four weeks

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It also slows down the digestive process and the speed at which food moves through the stomach, leading to a decreased appetite

PubMed Central , Malkud, Shashikant

Considering the totality of evidence from clinical trials, post-marketing reports and observational studies, alongside the generally low incidence rate of NAION, Novo Nordisk believes that the benefit-risk profile of semaglutide remains favorable, the spokesperson said.

While specific trials show slightly different results, semaglutide can reduce HBa1c levels between 0.6% and 1.6%