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If the patients skin type is Fitzpatrick Skin Type 4-6, has a history of hormonal patches, or has been sunburned before treatment, it will increase the risk of hyperpigmentation

In the absence of a control for the natural history of PD, findings from observational studies are of limited value

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doi: 10.3389/fimmu.2021.777147 57 HeH.ZhouJ.CaoS.LiuW.MeiZ.LiuM.et al

472 CD40L targeted therapy Platelets and immune cells communicate and regulate immune responses through CD40/CD40L interactions

Science 275 : 15931599