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Gastrointestinal problems are common initially, but starting with a lower dose and gradually increasing it might alleviate these side effects

GLP-1RAs directly enhance NK cell cytotoxicity, promote DC antigen presentation, and ameliorate the immunosuppressive microenvironment by inhibiting NET formation and regulating macrophage polarization, thereby offering novel perspectives for combination immunotherapy

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When your body is not adapted to this effect, the result is nausea, sometimes severe enough to stop the protocol entirely

However, it is surprising that existing studies investigating interventions targeting NETs formation have produced inconsistent results

(New York, NY: Wiley Intersci.), 153196