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While a more regulatory immune environment is beneficial in autoimmune conditions such as MS, the shift to Breg/Tregs/Th2 prevents the host immune system from detecting and lysing tumor cells and could fuel cancer growth via IL35 and IL10 producing Bregs (Figure 3)

NAD+ in redox reactions and sirtuin activation Nicotinamide adenine dinucleotide (NAD+) works as a key coenzyme for redox reactions

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The potential role of these pro-oxidant effects in the cancer preventive activity of green tea is not well understood

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