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doi: 10.1016/j.bbcan.2024.189086 120 SahaiEAstsaturovICukiermanEDeNardoDGEgebladMEvansRMet al

In the 1920 s, Warburg first demonstrated that cancer cells can increase their glucose consumption and produce lactate to fulfill their energy requirements, even under aerobic conditions [3]

134 Several other pharmacological compounds have been tested in small-scale or preliminary studies, including atorvastatin, 135,136 betahistine, 137 triamcinolone, 138 Ginkgo biloba, 139 melatonin, 140 oxytocin, 141 naltrexone, 142 and ondansetron

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Due to limited research, the roles of GPx5, GPx6, and GPx8 in tumorigenesis are still awaiting clarification