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This approach has become the standard with GLP-1 and GIP receptor agonists because rapid introduction at high doses often leads to nausea, vomiting, or diarrhea severe enough for patients to discontinue treatment

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The extra stimulation of GIP receptors makes insulin work better and creates extra pathways that reduce hunger

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At 2 h prior to oGTT, baseline blood glucose was measured, followed by a single subcutaneous injection of the test articles, AzaA8 (0.125 or 0.4 mg kg 1 ), Aib8 (0.125 or 0.4 mg kg 1 ), exendin-4 (0.125 mg kg 1 ), or saline

They started to propose that the formation of oxygen free radicals induced tissues and cell damage [2]