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Preclinical research evidence Animal Experiments Obese mouse model: After subcutaneous injection of AOD 9604 (250 g/kg) daily for 8 weeks, the body weight of obese mice decreased by 12%, the subcutaneous fat mass decreased by 25%, and the weight of epididymal adipose tissue decreased significantly

Toxicology Letters , vol

Data analysis was conducted using Prism GraphPad software

Each of the reaction mixtures were terminated by the addition of 250 l of ethyl acetate, extracted with 1 ml of methyl tert-butyl ether

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IGF-1 LR3 (Long R3 IGF-1) is the active mediator of growth-hormone signaling, modified for stability