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When it was recognized that pellagra, a condition marked by diarrhea, dermatitis, dementia, and mortality, could be treated with foods containing NAD+ precursors, particularly vitamin B3, the clinical significance of maintaining NAD+ levels was established in the early 1900s

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doi: 10.1016/j.colsurfb.2018.07.049 [DOI] [PubMed] [Google Scholar] 66.Katona G, Sabir F, Sipos B, et al

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