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After 48 h, the mice were sacrificed, and the heart, liver, spleen, lung, kidney, and tumor tissues were subsequently isolated, weighed, and nitrated for further analysis

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Cancer Res 77:41024115 von Heideman A, Berglund A, Larsson R, Nygren P (2010) Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

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established a system consisting of ROS-degradable hydrogel dressings, encapsulated biosafe NO donor L-Arg, and low concentration household disinfectant H 2 O 2 , which sustainably produced NO from the L-Arg in the hydrogel dressings under the stimulation of low levels of H 2 O 2 [107]