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Routine review is appropriate if cold extremities are mild, symmetrical, and not associated with pain or functional impairment

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10.1038/s41392-023-01442-3 54

Extremely high temperatures have been shown to denature cytoskeletal proteins, leading to their abnormal distribution in the oocyte 12 , leading mitochondria to relocate to the cell periphery instead of maintaining a homogeneous distribution throughout the cytoplasm 67

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Notably, pulsatile GH secretion persists even during continuous CJC-1295 stimulation, preserving physiological release patterns [2]