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Baseline metabolic status significantly impacts response rates

Tirzepatide is also administered as a once-weekly injection and follows a similar gradual dose-escalation schedule

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This extensive anatomical integration results in substantial overlap between GLP-1 signaling pathways and the mesolimbic dopamine system, which is central to reward-related behaviors

A systematic search of PubMed, Scopus, and Web of Science was conducted up to December 2024 according to PRISMA guidelines

GLP-1 medications typically cost between $800 and $1,300 per month without insurance coverage, depending on the specific drug and dose