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Slows gastric emptying , making you feel full longer, which can reduce food intake

Check Your Metabolic Health Markers Sometimes, the most meaningful changes happen inside your body before theyre visible externally

They reduce blood sugar, promote weight loss, and lower cardiovascular risk in appropriate patients

GLP-1 medications work partly by suppressing appetite and slowing gastric emptying. That's the mechanism behind the weight loss. But less food in means fewer vitamins and minerals in and the research now shows this isn't a theoretical concern. Butsch et al. (2025), the largest of the six studies in the Urbina review, tracked 461,382 GLP-1 users and found 22.4% had a new nutritional deficiency diagnosis within 12 months. Vitamin D was most common (13.6%), followed by nutritional anemia (4%), iron deficiency (3.2%), and B vitamin deficiency (2.6%). In a smaller dietary study (Johnson et al. 2025, Frontiers in Nutrition), 64% of GLP-1 users didn't meet iron intake recommendations, and 72% fell short on calcium.* This GLP-1 supplement covers the five most at-risk nutrients with bioavailable forms: methylcobalamin B12, chelated iron, chelated zinc, 5-MTHF folate, and vitamin D3

NICE's initial estimates assumed weight would return to baseline over two to three years our data suggests this happens in around 18 months

In summary, GLP-1 RAs help you lose weight by cutting your appetite, but eating much less food can mean youre also getting less of the nutrients (like vitamins, minerals, protein, and electrolytes) that your body needs to function