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The primary endpoint, major adverse cardiovascular events (MACE), was the time to first occurrence of a three-part composite outcome which included CV death, non-fatal myocardial infarction (MI) and non-fatal stroke

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77% of patients achieved more than 15% weight loss compared to 10% on diet and exercise counselling alone

The glucagon receptor component adds energy expenditure and lipolysis effects not seen in dual agonists, which may explain the larger effect sizes in Phase II data

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