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However, while approximately one third of approved drugs target GPCRs 8 , only two GPCR-targeting mAbs have been approved so far 9,10 , highlighting the challenges in generating and developing therapeutic antibodies against GPCRs

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To be market-worthy, the drug needed to remain active 24 hours a day, remain physically stable for long periods of time and be as or more potent than native GLP-1

Ischemic optic neuropathy (ION) occurs when blood flow to the optic nerve drops suddenly